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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Ayurveda and Integrative medicine
2022
July- September
;
13
(3)
:100587
[Epub ahead of Print]
Impact of AYUSH 64 as an adjunctive to standard of care in mild COVID 19 - An open-label randomized controlled pilot study
Anup Thakar (1)
,
Anup Thakar (1)
,
Mandip Goyal (1)
,
Mandip Goyal (1)
,
Sagar Bhinde (2)
,
Sagar Bhinde (2)
,
Kalpesh Panara (3)
,
Kalpesh Panara (3)
,
Swapnil Chaudhari (3)
,
Swapnil Chaudhari (3)
1. Institute of Teaching and Research in Ayurveda, Jamnagar, Gujarat, India. 2. Institute of Teaching and Research in Ayurveda, Jamnagar, Gujarat, India 3. Institute of Teaching and Research in Ayurveda, Jamnagar, Gujarat, India
Abstract
Background: Ayurveda herbal formulation AYUSH-64, proven to treat malaria and influenza-like illness in india was repurposed for COVID-19 patients considering preliminary evidances, however, scientific data was not available. Aim: To evaluate the preliminary efficacy and safety of AYUSH 64 as an add-on to standard of care in mild COVID19 patients. Materials and methods: A single centre, randomized, open-labeled, controlled, pilot study were conducted on mild COVID 19 confirmed patients. Patients allotted in interventional group (n = 41) recieved AYUSH 64, 3 gm per day in three divided dose for 14 days as an adjuvant to standard of care (SOC) whereas control group received SOC (n = 39) alone. Outcomes were reduction in WHO ordinal scale for clinical improvement, all-cause mortality, incidence of COVID19 symptoms among asymptomatic patients at baseline, use for oxygen therapy, use for a mechanical ventilator, the total duration of symptomatic phase and adverse events. Results: Mean score of WHO ordinal scale was reduced as time lapse in both the groups (f (1) = 20.5, p < 0.001) indicating clinical improvement among groups. There was no statistically significant difference in mean WHO ordinal scale between groups (f (1) = 0.98, p = 0.32). The proportion of asymptomatic patients progressing to the symptomatic stage is lower in AYUSH 64 group [OR, 0.68 (CI, 0.17-2.66)]. Mean days for the total duration of the symptomatic phase was also short in AYUSH 64 group (4.68 ± 3.29 days) compared to SOC group (5.81 ± 3.5 days). No incidence of the requirement of a mechanical ventilator, adverse drug reaction and death were observed in either of the groups. Conclusion: The findings of this pilot study show that an integrated approach of AYUSH 64 with SOC provide early trends of benefit by reduction in disease progression and in total symptom duration. However, its effects remains inconclusive on outcomes such as all cause mortality, use of oxygen therapy, invasive ventilator due to sparse outcomes. Keywords: AYUSH 64; Ayurveda; Indian traditional system of medicine; SARS-CoV-2.
DHARA ID:
D059286
Pubmed ID:
35600633
Link To Full Paper
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