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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Ayurveda and Integrative medicine
2019
Mar
:0
Cytotoxic and apoptotic inducing activity of Amoora rohituka leaf extracts in human breast cancer cells.
Singh Rajesh Kumar RK (1)
,
Ranjan Amit A (2)
,
Srivastava Akhileshwar Kumar AK (3)
,
Singh Monika M (4)
,
Shukla Anil Kumar AK (5)
,
Atri Neelam N (6)
,
Mishra Anurag A (7)
,
Singh Anil Kumar AK (7)
,
Singh Santosh Kumar SK (8)
1. Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; Department of Dravyaguna, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. 2. Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. 3. The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. 4. School of Biomedical Engineering, Indian Institute of Technology-BHU, Varanasi 221005, India. 5. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. 6. Department of Botany, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India. 7. Department of Dravyaguna, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. 8. Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: singhk71@yahoo.com.
Abstract
Amoora rohituka is described in Ayurveda, an Indian traditional system of medicine for management of disorders of blood, diseases of eye, helminthiasis disease, ulcer, liver disorders and splenomegaly. However, the leaves were not reported to have anticancer properties till date.This study was carried out to evaluate the cytotoxic potential of leaf extracts of Amoora rohituka.The leaves powder was macerated in petroleum ether, ethyl acetate and methanol and evaluated their anticancer activities in vitro. The phytochemical constituents of the active (ethyl acetate) extract were screened by FTIR analysis and phytochemical screening methods.The ethyl acetate extract (RLEA) showed the presence of alkaloids, flavonoids, steroids, tannins, saponins and terpenoids. The RLEA exhibited high cytotoxic effect against human breast cancer cells, MCF-7 (IC50 = 9.81 µg/mL) and induced apoptosis by altering nuclear morphology and DNA laddering. Wound healing assays explained the potency of extract to decrease the cell migration.The extract of Amoora rohituka leaves exhibited anticancer activity with less toxicity and it could be used for development of alternative drugs in the treatment of human breast cancer.Copyright © 2019 Transdisciplinary University, Bangalore and World Ayurveda Foundation. All rights reserved.
DHARA ID:
D056908
Pubmed ID:
30846274
Access to Full Paper Not Available
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