Home
|
About
|
Quick Start
|
FAQ
Beta Version 0.1
DHARA is an online index of articles on Ayurveda published in research journals worldwide.
Users Online:
415
Unfiltered
Classified Search
Enter Keyword Below :
Advanced
Ayu
2015 Jul-Sep
;
(3)
:0
In vivo antiarthritic activity of Rosa centifolia L. flower extract.
Kumar Rohit R (1)
,
Nair Vinod V (2)
,
Singh Surender S (1)
,
Gupta Yogendra Kumar YK (1)
1. Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. 2. IPR Division-05, Evalueserve SEZ (Gurgoan) Pvt. Ltd., Gurgoan, Haryana, India.
Abstract
Rosa centifolia L. (Rosaceae) have been used for the treatment of joint pain and rheumatoid arthritis (RA) in the traditional system of medicine.In this study, the antiarthritic activity of the alcoholic extract from the floral parts of R. centifolia was investigated.The anti-inflammatory and antiarthritic activity of R. centifolia alcoholic extract (RCAE: 32, 64, and 128 mg/kg) was evaluated using the carrageenan-induced paw edema and complete Freund's adjuvant (CFA) induced arthritis model. Serum from arthritic rats was collected for the estimation of pro-inflammatory cytokine levels. Further, the safety of RCAE was evaluated in an acute and sub-acute (28-day) oral toxicity study.RCAE (64 and 128 mg/kg) significantly (P < 0.01) inhibited carrageenan-induced paw edema at 1, 3, and 6 h post carrageenan challenge and demonstrated significant (P < 0.01) antiarthritic activity on days 3, 7, 14, and 21 day following CFA immunization. Further, RCAE (128 mg/kg) treatment also produced a significant (P < 0.01) decrease in circulating pro-inflammatory cytokine levels as compared with control. Further, no toxicologically significant treatment-related effects were observed in the oral sub-acute toxicity study conducted with the extract.The result of study demonstrates the antiarthritic activity of R. centifolia and validates its traditional use for the treatment of RA.
DHARA ID:
D056402
Pubmed ID:
27313424
Access to Full Paper Not Available
Copyright
|
Disclaimer
|
Feedback
|
Updates
|
Contact
Developed and maintained by AVP Research Foundation (Formerly AVT Institute for Advanced Research), 136/137, Trichy Road, Ramanathapuram, Coimbatore - 641045, Tamil Nadu, India
Funded by Central Council for Research in Ayurvedic Sciences, Dept. of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi