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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Brain Research Bulletin
2017
Oct
:0
Role of ethanolic extract of Bacopa monnieri against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice model via inhibition of apoptotic pathways of dopaminergic neurons.
Singh Babita B (1)
,
Pandey Shivani S (2)
,
Yadav Satyndra Kumar SK (3)
,
Verma Rajesh R (4)
,
Singh Surya Pratap SP (5)
,
Mahdi Abbas Ali AA (1)
1. Department of Biochemistry, KGMU, Lucknow 226003, India. 2. Department of Biochemistry, KGMU, Lucknow 226003, India. Electronic address: drshivani111263@gmail.com. 3. Department of Biological Science, Yathartha Institute, Lucknow 226014, India. 4. Department of Neurology, KGMU, Lucknow 226003, India. 5. Department of Biochemistry, Institute of Science, BHU, Varanasi 221005, India.
Abstract
Parkinson's disease (PD) is a neurodegenerative disease which causes rigidity, resting tremor and postural instability. The neuroprotective effects of an ethanolic extract of Bacopa monnieri (BM) were evaluated in a Parkinsonian mice model induced by the MPTP. The present study investigates the mechanisms of neuroprotection elicited by BM, an herb traditionally recognized by the Indian system of medicine, Ayurveda. An ethanolic extract of BM was co-treated with the MPTP induced mouse model of PD and was shown to significantly rescue the motor behaviour (Rotarod, Grip Strength and Foot Printing test). Furthermore, on biochemical parameters too BM significantly showed protective effect as Catalase, LPO, Nitrite, SOD, GR, GPx parameters showed marked improvement and levels of Dopamine, DOPAC and HVA were enhanced significantly. There was a significant reduction in tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra (SN) in MPTP treated group, which was considerably restored by the use of BM extract. BM also facilitated neuroprotection by creating an anti-apoptotic environment indicated by reduced apoptotic (Bax and caspase-3) and increased levels of anti-apoptotic (Bcl2) protein expression, respectively. Altogether, the present study suggests that BM treatment provides nigrostriatal dopaminergic neuroprotection against MPTP induced Parkinsonism by the modulation of oxidative stress and apoptotic machinery possibly accounting for the behavioural effects.Copyright © 2017. Published by Elsevier Inc.
DHARA ID:
D056297
Pubmed ID:
29032054
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