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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Pharmaceutical Biology
2017
Dec
;
(1)
:0
Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves.
Pandey Abhishek A b IPS College of Pharmacy , Gwalior , India. (1)
,
Kaushik Atul A (2)
,
Wanjari Manish M (3)
,
Dey Yadu Nandan YN (3)
,
Jaiswal Bhagat Singh BS (4)
,
Dhodi Anamika A (5)
1. a Department of Pharmaceutical Sciences , IFTM University , Moradabad , India. 2. b IPS College of Pharmacy , Gwalior , India. 3. c National Research Institute for Ayurveda-Siddha Human Resource Development , Gwalior , India. 4. d School of Studies in Pharmaceutical Sciences, Jiwaji University , Gwalior , India. 5. e School of Studies in Microbiology, Jiwaji University , Gwalior , India.
Abstract
Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae), commonly called 'Bui', is a medicinal plant of the arid region. It is used for the treatment of inflammatory disorders, such as rheumatic pain, and healing of wounds, which are associated with oxidative stress.The present study evaluated the antioxidant potential of Aerva pseudotomentosa leaves by in vitro models and its anti-inflammatory effect in rats.The aqueous extract (APAE) was analyzed by HPTLC and HPLC. The antioxidant effect of APAE was evaluated by various in vitro methods [DPPH (1, 1-diphenyl-2-picryl-hydrazil) and hydrogen peroxide free radical scavenging, reducing power, and anti-lipid peroxidation assays]. Anti-inflammatory effect was studied in carrageenan and formalin-induced paw oedema models in rats. APAE (200 and 400?mg/kg) and standard drug, indomethacin (10?mg/kg), were administered orally 1?h before carrageenan/formalin administration and inflammation was noted up to 5?h.HPLC analysis of APAE revealed the presence of rutin. APAE showed significant scavenging effect on DPPH (IC50 49.37?µg/mL) and peroxide (IC50 49.37?µg/mL) radicals. The extract exhibited reducing potential and inhibition of lipid peroxidation. APAE treatment significantly attenuated mean increase in paw volume and exhibited inhibition of paw oedema in both in vivo models with inhibition of 45.11% and 49.42%, respectively at 5?h.APAE exhibited in vitro antioxidant and anti-inflammatory activities. Anti-inflammatory effect of APAE may be attributed to its antioxidant potential, due to the presence of rutin and other phenolics. This study substantiates folk use of leaves in inflammatory disorders.
DHARA ID:
D056119
Pubmed ID:
28454506
Access to Full Paper Not Available
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