Home
|
About
|
Quick Start
|
FAQ
Beta Version 0.1
DHARA is an online index of articles on Ayurveda published in research journals worldwide.
Users Online:
441
Unfiltered
Classified Search
Enter Keyword Below :
Advanced
Pharmaceutical Biology
2017
Dec
;
(1)
:0
Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats.
Dey Yadu Nandan YN c Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University , Meerut , Uttar Pradesh , India. (1)
,
Sharma Garima G (2)
,
Wanjari Manish M MM (1)
,
Kumar Dharmendra D e Faculty of Pharmaceutical Sciences, UCSI University , Kaula Lumpur , Malaysia. (3)
,
Lomash Vinay V (4)
,
Jadhav Ankush D AD (1)
1. a National Research Institute for Ayurveda-Siddha Human Resource Development , Gwalior , Madhya Pradesh , India , (Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, New Delhi, India). 2. b School of Studies in Biomedical Technology, Jiwaji University , Gwalior , Madhya Pradesh , India. 3. c Centre for Advanced Research in Pharmaceutical Sciences, Shobhit University , Meerut , Uttar Pradesh , India. 4. d Shriram Institute for Industrial Research , New Delhi , India.
Abstract
The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders.The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats.Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500?mg/kg) or standard drug, prednisolone (PRDS) (4?mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48?h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon.APME or APAE pretreatment significantly (p?.05-.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p?.001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p?.05-.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis.APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, ß-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action.
DHARA ID:
D056073
Pubmed ID:
27600166
Access to Full Paper Not Available
Copyright
|
Disclaimer
|
Feedback
|
Updates
|
Contact
Developed and maintained by AVP Research Foundation (Formerly AVT Institute for Advanced Research), 136/137, Trichy Road, Ramanathapuram, Coimbatore - 641045, Tamil Nadu, India
Funded by Central Council for Research in Ayurvedic Sciences, Dept. of AYUSH, Ministry of Health and Family Welfare, Government of India, New Delhi