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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of the science of food and agriculture
2016
Mar
:0
Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study.
Kar Amit A (1)
,
Pandit Subrata S (1)
,
Mukherjee Kakali K (1)
,
Bahadur Shiv S (1)
,
Mukherjee Pulok K PK (1)
1. School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.
Abstract
Andrographis paniculata, Bacopa monnieri, Centella asiatica are mentioned in Ayurveda for the management of neurodegenerative disorders. These plants and their phytomolecules like andrographolide, bacoside A and asiaticoside were studied for their inhibition potential on pooled CYP450 as well as human CYP3A4, CYP2D6, CYP2C9 and CYP1A2 by CYP-CO Complex assay and Fluorogenic assay respectively followed by IC50 determination. Quantification of bioactive compounds present in the extracts was done by RP-HPLC. Heavy metal content in the selected medicinal plants was determined by Atomic Absorption Spectroscopy.CYP-CO Complex assay indicate significantly lesser inhibition potential than standard inhibitor (p?
DHARA ID:
D055861
Pubmed ID:
27030208
Access to Full Paper Not Available
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