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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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European Journal of Pharmacology
2015
Jun
:0
Current knowledge and pharmacological profile of berberine: An update.
Kumar Anil A (1)
,
Ekavali Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, India.
,
Chopra Kanwaljit K (2)
,
Mukherjee Madhurima M (2)
,
Pottabathini Raghavender R (2)
,
Dhull Dinesh K DK (2)
1. Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, India. Electronic address: kumaruips@yahoo.com. 2. Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh 160014, India.
Abstract
Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclinical studies demonstrate ameliorative effect of berberine against several disorders including metabolic, neurological and cardiological problems. This review provides a summary regarding the pharmacokinetic and pharmacodynamic features of berberine, with a focus on the different mechanisms underlying its multispectrum activity. Studies regarding the safety profile, drug interactions and important clinical trials of berberine have also been included. Clinical trials with respect to neurological disorders need to be undertaken to exploit the beneficiary effects of berberine against serious disorders such as Alzheimer's and Parkinson's disease. Also, clinical studies to detect rare adverse effects of berberine need to be initiated to draw a complete safety profile of berberine and strengthen its applicability.Copyright © 2015 Elsevier B.V. All rights reserved.
DHARA ID:
D055534
Pubmed ID:
26092760
Access to Full Paper Not Available
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