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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Phytotherapy Research : PTR
2015
Jun
:0
Blood Glucose-lowering Effect of T.?procumbens L.: A Pilot Clinical Study in Individuals with Type 2 Diabetes.
Desai Gauri S GS Bhagawati Industrial and Organic Products, Kolhapur, Maharashtra, India. (1)
,
Desai Shirish V SV (2)
,
Gavaskar Rajendra S RS (3)
,
Mulabagal Vanisree V (4)
,
Wu Yonnie Y (5)
,
Mathews Suresh T ST (1)
1. Department of Nutrition and Dietetics, Boshell Diabetes and Metabolic Diseases Research Program, Auburn University, Auburn, AL, 36830, USA. 2. Bhagawati Industrial and Organic Products, Kolhapur, Maharashtra, India. 3. GTL Foundation, Sindhudurg, Maharashtra, India. 4. Department of Chemical Engineering, Tuskegee University, Tuskegee, AL, 36088, USA. 5. Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, 36849, USA.
Abstract
Traditional knowledge, in vitro studies, and studies using animal models suggest that Tridax procumbens L. exhibits blood glucose-lowering properties and antiinflammatory effects. In this study, we evaluated the blood glucose-lowering effect of T.?procumbens supplementation in individuals with type 2 diabetes. An extract (asava) of T.?procumbens L. was prepared following Ayurveda guidelines. Chemical and microbial analyses indicated presence of phenolics, flavonoids, and carotenoids, and absence of microbial contamination, aflatoxins, heavy metals, and pesticide residues. A chemical fingerprint of T.?procumbens L. asava, developed using Ultra high pressure liquid chromatography/electron spray ionization-mass spectrometry (UPLC/ESI-MS) in negative mode, suggest the presence of several compounds including polyphenols. T.?procumbens asava demonstrated strong total antioxidant capacity, Fe(3+) reducing potential, Fe(2+) chelation, H2 O2 scavenging activity, and inhibition of lipid peroxidation. We recruited 20 type 2 diabetic individuals from Kolhapur, India. Participants received 15?mL of T.?procumbens asava, twice daily, for 4?weeks, while continuing their prescribed antidiabetic medications. Fasting blood glucose decreased by 11% in men (p?
DHARA ID:
D055533
Pubmed ID:
26096804
Access to Full Paper Not Available
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