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Pharmaceutical Biology 2010 Nov ; (11) :0
Potential of Baliospermum montanum against compound 48/80-induced systemic anaphylaxis.

Abstract
Decoctions of Baliospermum montanum Müll. Arg. (Euphorbiaceae) leaves are reported to be useful in the treatment of asthma and other respiratory complications in the Ayurvedic system. Objective: To evaluate the mast cell stabilization and antihistaminic activities of the chloroform (BMLC) and ethanol (BMLE) extracts of the leaves of Baliospermum montanum.The stabilization potential was studied on mouse peritoneal mast cells and the antihistaminic activity was carried out by determining the mortality rate of mice treated with toxicant (compound 48/80) and the effect on elevation of histamine release upon degranulation.The increased number of intact mast cells (43.640 ± 1.7% and 61.57 ± 1.79% at 200 and 400?mg/ kg, respectively) suggested that the BMLC stabilized the mast cell degranulation and showed decreased elevation of histamine.BMLC extract was found to be most effective against degranulation and release of histamine from mast cells. Identifying the lead from this plant will be a definite target for treating allergic diseases.

DHARA ID: D053072 Pubmed ID: 20818926


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