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FEBS letters 2011 Jan ; (1) :0
Over-expression of mitochondrial heat shock protein 70 suppresses programmed cell death in rice.
Qi Y,   Wang H,   Zou Y,   Liu C,   Liu Y,   Wang Y,   Zhang W  

Abstract
In this study, we identified and functionally characterized the mitochondrial heat shock protein 70 (mtHsp70). Over-expression of mtHsp70 suppressed heat- and H(2)O(2)-induced programmed cell death (PCD) in rice protoplasts, as reflected by higher cell viability, decreased DNA laddering and chromatin condensation. Mitochondrial membrane potential (??(m)) after heat shock was destroyed gradually in protoplasts, but mtHsp70 over-expression showed higher ??(m) relative to the vector control cells, and partially inhibited cytochrome c release from mitochondria to cytosol. Heat treatment also significantly increased reactive oxygen species (ROS) generation, a phenomenon not observed in protoplasts over-expressing mtHsp70. Together, these results suggest that mtHsp70 may suppress PCD in rice protoplasts by maintaining mitochondrial ??(m) and inhibiting the amplification of ROS.Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

DHARA ID: D016134 Pubmed ID: 21130768


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