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Journal of Natural Products 2011 Jan ; (1) :0
Cytotoxic amide alkaloids from Piper boehmeriaefolium.
Tang GH,   Chen DM,   Qiu BY,   Sheng L,   Wang YH,   Hu GW,   Zhao FW,   Ma LJ,   Wang H,   Huang QQ,   Xu JJ,   Long CL,   Li J  

Abstract
Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 µg/mL.

DHARA ID: D014766 Pubmed ID: 21158422


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