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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Nutrition reviews
2025
Jun
;
83
(6)
:1152-1170
Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery
Ashok Kumar Mandal (1)
,
Ankit Sahoo (2)
,
Waleed H Almalki (3)
,
Salem Salman Almujri (4)
,
Abdulrahman Alhamyani (5)
,
Alhussain Aodah (6)
,
Nabil K Alruwaili (7)
,
Sharifah Zamiah Binti Syed Abdul Kadir (1)
,
Rambha Kumari Mandal (8)
,
Rami A Almalki (9)
,
Jonathan A Lal (10)
,
Mahfoozur Rahman (11)
1. Department of Pharmacology, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. 2. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh 211007, India 3. Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia 4. Department of Pharmacology, College of Pharmacy, King Khalid University, Asir-Abha 61421, Saudi Arabia. 5. Pharmaceuticals Chemistry Department, Faculty of Clinical Pharmacy, Al Baha University, Al Baha 65779, Saudi Arabia. 6. College of Pharmacy, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia. 7. Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakakah 72341, Saudi Arabia. 8. Patanjali Ayurveda Medical College and Research Centre, Dhulikhel 45200, Nepal. 9. Clinical Pharmacy Unit, Pharmaceutical Care Department, King Faisal Hospital, Makkah Health Cluster, Makkah 24382, Saudi Arabia. 10. Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology, and Sciences, Prayagraj, Uttar Pradesh 211007, India. 11. Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh 211007, India.
Abstract
Obesity is a global health concern that requires urgent investigation and management. While synthetic anti-obesity medications are available, they come with a high risk of side-effects and variability in their efficacy. Therefore, natural compounds are increasingly being used to treat obesity worldwide. The proposition that naturally occurring compounds, mainly polyphenols, can be effective and safer for obesity management through food and nutrient fortification is strongly supported by extensive experimental research. This review focuses on the pathogenesis of obesity while reviewing the efficacy of an array of phytoactives used for obesity treatment. It details mechanisms such as enzyme inhibition, energy expenditure, appetite suppression, adipocyte differentiation, lipid metabolism, and modulation of gut microbiota. Comprehensive in vitro, in vivo, and preclinical studies underscore the promise of phytoactives in combating obesity, which have been thoroughly reviewed. However, challenges, such as poor bioavailability and metabolism, limit their potential. Advances in nanomedicines may overcome these constraints, offering a new avenue for enhancing the efficacy of phytoactives. Nonetheless, rigorous and targeted clinical trials are essential before applying phytoactives as a primary treatment for obesity.
DHARA ID:
D064192
Pubmed ID:
39331591
Link To Full Paper
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