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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Drug delivery and translational research
2025
Jun
;
15
(6)
:1935-1961
Navigating liver cancer: Precision targeting for enhanced treatment outcomes
Ankit Jain (1)
,
Ashwini Kumar Mishra (2)
,
Pooja Hurkat (3)
,
Satish Shilpi (4)
,
Nishi Mody (3)
,
Sanjay Kumar Jain (3)
1. Department of Pharmacy, Birla Institute of Technology and Science (BITS), Pilani Campus, Pilani, Rajasthan, 333031, India. ankitjainsagar@gmail.com 2. Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra, 425405, India, Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India 3. Dr. Hari Singh Gour Central University, Sagar, 470003, MP, India 4. School of Pharmaceuticals and Population Health Informatics, FOP, DIT University, Dehradun, Uttarakahnad, India
Abstract
Cancer treatments such as surgery and chemotherapy have several limitations, including ineffectiveness against large or persistent tumors, high relapse rates, drug toxicity, and non-specificity of therapy. Researchers are exploring advanced strategies for treating this life-threatening disease to address these challenges. One promising approach is targeted drug delivery using prodrugs or surface modification with receptor-specific moieties for active or passive targeting. While various drug delivery systems have shown potential for reaching hepatic cells, nano-carriers offer significant size, distribution, and targetability advantages. Engineered nanocarriers can be customized to achieve effective and safe targeting of tumors by manipulating physical characteristics such as particle size or attaching receptor-specific ligands. This method is particularly advantageous in treating liver cancer by targeting specific hepatocyte receptors and enzymatic pathways for both passive and active therapeutic strategies. It highlights the epidemiology of liver cancer and provides an in-depth analysis of the various targeting approaches, including prodrugs, liposomes, magneto-liposomes, micelles, glycol-dendrimers, magnetic nanoparticles, chylomicron-based emulsion, and quantum dots surface modification with receptor-specific moieties. The insights from this review can be immensely significant for preclinical and clinical researchers working towards developing effective treatments for liver cancer. By utilizing these novel strategies, we can overcome the limitations of conventional therapies and offer better outcomes for liver cancer patients.
DHARA ID:
D064116
Pubmed ID:
39847205
Link To Full Paper
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