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International Journal of Ayurveda Research 2023 January - March ; 3 (1) :15-27
Experimental evidence to the untapped potential of Ayurvedic herb, Ashwagandha: Bench-to-Bedside

Abstract
The last century has witnessed a major transition in every aspect of human life. Advancement in science and technologies, health, agriculture and medical sectors have tremendously improved food and living standards. A significant surge in human life expectancy has resulted in an increase in aging society triggering alters in global population demographics, social, and health-care supporting systems. Industrialization of lifestyle with excessive use of chemicals has sparked another negative feedback loop, threatening quality of life (QOL), and increasing sense of stress and anxiety. Together, these scenarios have posed new challenges to manage age- and stress-related ailments and maintain good QOL. Traditional home medicine systems, in contrast to use of chemicals/drugs, depending on the use of natural resources/ways to boost our built-in defense mechanisms. Ayurveda (Ayu means life and Veda means knowledge) is the world’s oldest home medicine system of Indian origin that continues to be a living tradition with a history of about ~5000 years. Ayurvedic medicine, with its deeply trusted concept of holistic approach, is based on maintaining the harmonious balance of different life-elements to treat/prevent diseases. Ayurvedic system involves the use of variety of herbs/plants, yoga, and relaxation techniques. Among a large number of plants described to enhance QOL in Ayurveda, Ashwagandha (Withania somnifera (L.) Dunal) categorized as Rasayana (a rejuvenating herb) is also appraised as “Queen of Ayurveda”. In this review, we discuss the experimental evidence of the therapeutic activities of Ashwagandha and its untapped potential for the treatment of stress, brain ailments, cancer and COVID-19.

DHARA ID: D063908


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