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DHARA is an online index of articles on Ayurveda published in research journals worldwide.
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Journal of Ayurveda and Integrative medicine
In vitro evaluation of phytochemicals from Murivenna oil and Wattakaka volubilis leaf on fibroblast cells
Elakkiya Venugopal (1)
,
Sujith Subash Eranezhath (2)
,
Amitava Bhattacharya (3)
,
Selvakumar Rajendran (4)
1. Tissue Engineering Laboratory, PSG Institute of Advanced Studies, Coimbatore, Tamil Nadu, India. 2. Basic and Translational Research Department, AVP Research Foundation, Coimbatore, Tamil Nadu, India. 3. Nanoscience and Technology Laboratory, Department of Electronics and Communication Engineering, PSG College of Technology, Coimbatore, Tamil Nadu, India. 4. Tissue Engineering Laboratory, PSG Institute of Advanced Studies, Coimbatore, Tamil Nadu, India, Nanobiotechnology Laboratory, PSG Institute of Advanced Studies, Coimbatore, Tamil Nadu, India.
Abstract
Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common joint diseases, affecting 0.5% to 1% of the general population worldwide. Murivenna oil is a commercial medicine used in ayurveda for the treatment of acute injuries like sprain, cramps, closed, fractures and bruises. Murivenna has marked results in the treatment of arthritic disorders like pain, swelling, stiffness and other acute as well as chronic ailment present in the joints. Ayurvedic physicians have found Hemajeevanti (Wattakaka volubilis) to be equally effective as Murivenna. Preparation of Murivenna requires eight different medicinal plants whereas Hemajeevanti requires only one plant Wattakaka volubilis. Hence Hemajeevanti is substituted for Murivenna. Methods: The present study investigates the influence of active phytochemical components present in the leaf extract of W. volubilis and murivenna on fibroblast cells. Various solvents were employed to extract the components present and suitable solvent was selected based on the viability analysis on fibroblast cells and scavenging activity. Results: Ethyl acetate was found to be the best solvent for phytochemical extraction. Phytochemical screening was carried out using standard protocols to analyze the compounds present in murivenna and W. volubilis. Conclusion: From the results ethyl acetate extract was found to be effective towards growth and proliferation of fibroblast cells. Hence, the ethyl acetate extract of W. volubilis may used for drug development process for bone related injuries.
DHARA ID:
D063869
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